Ongoing Funded Projects:
Continuous Polymorphic Crystallisation of Active Pharmaceutical Ingredients in a Slug-Flow-Cooling-Crystalliser
SERB-Early Career Researcher Award (2018-2021)
Continuous crystallisation offers potential for higher efficiency, better resource utilisation, and lower operating cost than comparable batch units. They also result in better control of crystal purity and crystal size distribution which may otherwise significantly affect product qualities and also result in batch to batch variations in conventional batch vessels. In a batch crystalliser, the entire crystalliser is monitored and controlled as a single unit which indisputably results in local macroscopic fluctuations. As a result, random nucleation events, crystal attrition due to collision with agitator as well as other particles, reactor scaling, and temperature gradient within crystalliser becomes unavoidable in an industrial crystallisation process. These in turn affects product quality in terms of purity and particle size distribution and increases the difficulty in scaling up.
The primary objective of this project is to establish a continuous crystalliser for small organic molecules typically used as APIs. The unit will be able to continuously produce crystals of consistent quality with higher resource and energy efficiency than conventional batch crystallisers. The method will be scalable for manufacturing purpose and provide additional control over crystallisation process.